Human Immunodeficiency virus is an existing pathogen for which the development of drugs, vaccines, anti viral therapy has seen little success. The HIV-1 Integrase(HIV-1 IN) is a potential target for antiviral drugs since it plays a vital role in facilitating the integration of viral DNA into the host cell genome. Our present quest concentrates on discovering anti HIV compounds that are present in the ethanolic extract of Nilavembu (Andrographis panniculata Nees). It is an important medicinal herb belonging to the family Acanthaceae. The phytochemicals extracted from Andrographis panniculata were docked against the enzyme HIV-1 integrase. The results reveal that those compounds are active against HIV-1 integrase and will be effective for doing further research on plant Andrographis panniculata in drug designing against HIV.