Bland–Altman plot showing the mean difference and limits of agreement for the heart rate fragment containing a partial complex seizure in patient two. There is a negligible

bias, and limits of agreement aremuch lower thanwhatweremeasured during the tonic–clonic seizure. (B) Heart rate signals acquiredwith bothmethods for the same seizure fragment.

The depicted continuous lines are based on 1-Hz measurements (one datapoint per second). The red points are the outliers in Fig. 3A. Panel C shows the ECG signalwith an electrode connection

problem during the seizure leading to a flat line in the ECG. The interpolated heart rate generated outliers in the Bland–Altman plot. (For interpretation of the references to color in

this figure legend, the reader is referred to the web version of this article.)