This book is thought as a highly practical guide which can help the readers to design measurement and control systems based upon Raspberry Pi. These systems can comprise external electronic circuits controlled by programs written in Python. Projects described in the book illustrate processing digital and analog signals and using I/O expanders. Since many measurement systems process analog signals, the guide contains a brief theory and practical applications dedicated to use of popular high-resolution Analog-To-Digital converters. The guide contains projects which illustrate processing small signals with instrumentation amplifiers and measuring frequencies of digital and analog signals using high-precision Frequency-To-Voltage converters.